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Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids
The clinical efficacy of opiates for pain control is severely limited by analgesic tolerance and hyperalgesia. Herein we show that chronic morphine upregulates both the sphingolipid ceramide in spinal astrocytes and microglia, but not neurons, and spinal sphingosine-1-phosphate (S1P), the end-produc...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Society for Neuroscience
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3000610/ https://ncbi.nlm.nih.gov/pubmed/21084596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2391-10.2010 |
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