Supraspinal Peroxynitrite Modulates Pain Signaling by Suppressing the Endogenous Opioid Pathway

Peroxynitrite (PN, ONOO(−)) is a potent oxidant and nitrating agent that contributes to pain through peripheral and spinal mechanisms, but its supraspinal role is unknown. We present evidence here that PN in the rostral ventromedial medulla (RVM) is essential for descending nociceptive modulation in...

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Detalhes bibliográficos
Main Authors: Little, Joshua W., Chen, Zhoumou, Doyle, Timothy, Porreca, Frank, Ghaffari, Mahsa, Bryant, Leesa, Neumann, William L., Salvemini, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511865/
https://ncbi.nlm.nih.gov/pubmed/22875915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6345-11.2012
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