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Supraspinal Peroxynitrite Modulates Pain Signaling by Suppressing the Endogenous Opioid Pathway
Peroxynitrite (PN, ONOO(−)) is a potent oxidant and nitrating agent that contributes to pain through peripheral and spinal mechanisms, but its supraspinal role is unknown. We present evidence here that PN in the rostral ventromedial medulla (RVM) is essential for descending nociceptive modulation in...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3511865/ https://ncbi.nlm.nih.gov/pubmed/22875915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6345-11.2012 |
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