Supraspinal Peroxynitrite Modulates Pain Signaling by Suppressing the Endogenous Opioid Pathway

Peroxynitrite (PN, ONOO(−)) is a potent oxidant and nitrating agent that contributes to pain through peripheral and spinal mechanisms, but its supraspinal role is unknown. We present evidence here that PN in the rostral ventromedial medulla (RVM) is essential for descending nociceptive modulation in...

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Bibliografski detalji
Glavni autori: Little, Joshua W., Chen, Zhoumou, Doyle, Timothy, Porreca, Frank, Ghaffari, Mahsa, Bryant, Leesa, Neumann, William L., Salvemini, Daniela
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2012
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511865/
https://ncbi.nlm.nih.gov/pubmed/22875915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6345-11.2012
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