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Probing the Nucleus Model for Oligomer Formation during Insulin Amyloid Fibrillogenesis
We find evidence for a direct transition of insulin monomers into amyloid fibrils without measurable concentrations of oligomers or protofibrils, suggesting that fibrillogenesis may occur directly from assembly of denaturing insulin monomers rather than by successive transitions through protofibril...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3000482/ https://ncbi.nlm.nih.gov/pubmed/21156140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.10.010 |
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