Probing the Nucleus Model for Oligomer Formation during Insulin Amyloid Fibrillogenesis

We find evidence for a direct transition of insulin monomers into amyloid fibrils without measurable concentrations of oligomers or protofibrils, suggesting that fibrillogenesis may occur directly from assembly of denaturing insulin monomers rather than by successive transitions through protofibril...

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Hlavní autoři: Pease, Leonard F., Sorci, Mirco, Guha, Suvajyoti, Tsai, De-Hao, Zachariah, Michael R., Tarlov, Michael J., Belfort, Georges
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2010
Témata:
Protein
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000482/
https://ncbi.nlm.nih.gov/pubmed/21156140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.10.010
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