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Isolating Toxic Insulin Amyloid Reactive Species that Lack β-Sheets and Have Wide pH Stability

Amyloid diseases, including Alzheimer's disease, are characterized by aggregation of normally functioning proteins or peptides into ordered, β-sheet rich fibrils. Most of the theories on amyloid toxicity focus on the nuclei or oligomers in the fibril formation process. The nuclei and oligomers...

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Detalhes bibliográficos
Main Authors: Heldt, Caryn L., Kurouski, Dmitry, Sorci, Mirco, Grafeld, Elizabeth, Lednev, Igor K., Belfort, Georges
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117171/
https://ncbi.nlm.nih.gov/pubmed/21641325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.04.046
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