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Disulfide Bridges Remain Intact while Native Insulin Converts into Amyloid Fibrils

Amyloid fibrils are β-sheet-rich protein aggregates commonly found in the organs and tissues of patients with various amyloid-associated diseases. Understanding the structural organization of amyloid fibrils can be beneficial for the search of drugs to successfully treat diseases associated with pro...

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Dettagli Bibliografici
Autori principali: Kurouski, Dmitry, Washington, Jacqueline, Ozbil, Mehmet, Prabhakar, Rajeev, Shekhtman, Alexander, Lednev, Igor K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365881/
https://ncbi.nlm.nih.gov/pubmed/22675475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036989
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