Probing the Nucleus Model for Oligomer Formation during Insulin Amyloid Fibrillogenesis

We find evidence for a direct transition of insulin monomers into amyloid fibrils without measurable concentrations of oligomers or protofibrils, suggesting that fibrillogenesis may occur directly from assembly of denaturing insulin monomers rather than by successive transitions through protofibril...

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Autors principals: Pease, Leonard F., Sorci, Mirco, Guha, Suvajyoti, Tsai, De-Hao, Zachariah, Michael R., Tarlov, Michael J., Belfort, Georges
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2010
Matèries:
Protein
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000482/
https://ncbi.nlm.nih.gov/pubmed/21156140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.10.010
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