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Probing the Nucleus Model for Oligomer Formation during Insulin Amyloid Fibrillogenesis
We find evidence for a direct transition of insulin monomers into amyloid fibrils without measurable concentrations of oligomers or protofibrils, suggesting that fibrillogenesis may occur directly from assembly of denaturing insulin monomers rather than by successive transitions through protofibril...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Biophysical Society
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3000482/ https://ncbi.nlm.nih.gov/pubmed/21156140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.10.010 |
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