Probing the Nucleus Model for Oligomer Formation during Insulin Amyloid Fibrillogenesis

We find evidence for a direct transition of insulin monomers into amyloid fibrils without measurable concentrations of oligomers or protofibrils, suggesting that fibrillogenesis may occur directly from assembly of denaturing insulin monomers rather than by successive transitions through protofibril...

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Bibliografiske detaljer
Main Authors: Pease, Leonard F., Sorci, Mirco, Guha, Suvajyoti, Tsai, De-Hao, Zachariah, Michael R., Tarlov, Michael J., Belfort, Georges
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2010
Fag:
Protein
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000482/
https://ncbi.nlm.nih.gov/pubmed/21156140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.10.010
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