Probing the Nucleus Model for Oligomer Formation during Insulin Amyloid Fibrillogenesis

We find evidence for a direct transition of insulin monomers into amyloid fibrils without measurable concentrations of oligomers or protofibrils, suggesting that fibrillogenesis may occur directly from assembly of denaturing insulin monomers rather than by successive transitions through protofibril...

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Bibliografische gegevens
Hoofdauteurs: Pease, Leonard F., Sorci, Mirco, Guha, Suvajyoti, Tsai, De-Hao, Zachariah, Michael R., Tarlov, Michael J., Belfort, Georges
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Biophysical Society 2010
Onderwerpen:
Protein
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000482/
https://ncbi.nlm.nih.gov/pubmed/21156140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.10.010
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