Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

PURPOSE: Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten to compromise gains made in systemic chemotherapy. The blood-tumor barrier (BTB) is compromised in many brain metastases, however, the extent to which this influences chemother...

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Huvudupphovsmän: Lockman, Paul R., Mittapalli, Rajendar K., Taskar, Kunal S., Rudraraju, Vinay, Gril, Brunilde, Bohn, Kaci A., Adkins, Chris E., Roberts, Amanda, Thorsheim, Helen R., Gaasch, Julie A., Huang, Suyun, Palmieri, Diane, Steeg, Patricia S., Smith, Quentin R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999649/
https://ncbi.nlm.nih.gov/pubmed/20829328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1564
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