Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

PURPOSE: Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten to compromise gains made in systemic chemotherapy. The blood-tumor barrier (BTB) is compromised in many brain metastases, however, the extent to which this influences chemother...

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Autores principales: Lockman, Paul R., Mittapalli, Rajendar K., Taskar, Kunal S., Rudraraju, Vinay, Gril, Brunilde, Bohn, Kaci A., Adkins, Chris E., Roberts, Amanda, Thorsheim, Helen R., Gaasch, Julie A., Huang, Suyun, Palmieri, Diane, Steeg, Patricia S., Smith, Quentin R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999649/
https://ncbi.nlm.nih.gov/pubmed/20829328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1564
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