Metabolomics Identifies Novel Hnf1α-Dependent Physiological Pathways in Vivo

Mutations in the HNF1A gene cause maturity-onset diabetes of the young type 3, one of the most common genetic causes of non-insulin-dependent (type 2) diabetes mellitus. Although the whole-body Hnf1a-null mouse recapitulates the low insulin levels and high blood glucose observed in human maturity-on...

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Auteurs principaux: Bonzo, Jessica A., Patterson, Andrew D., Krausz, Kristopher W., Gonzalez, Frank J.
Format: Artigo
Langue:Inglês
Publié: The Endocrine Society 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999475/
https://ncbi.nlm.nih.gov/pubmed/20943816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0130
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