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Angiogenin abolishes cell-free protein synthesis by specific ribonucleolytic inactivation of ribosomes.
Angiogenin is a potent inhibitor of cell-free protein synthesis. When incubated with rabbit reticulocyte lysate at a concentration of 40-60 nM, it completely abolishes the capacity of the lysate to support protein synthesis. The inhibition appears to be due to its ribonucleolytic activity since it (...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1987
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299536/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3479795/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.23.8330 |
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