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Angiogenin abolishes cell-free protein synthesis by specific ribonucleolytic inactivation of ribosomes.

Angiogenin is a potent inhibitor of cell-free protein synthesis. When incubated with rabbit reticulocyte lysate at a concentration of 40-60 nM, it completely abolishes the capacity of the lysate to support protein synthesis. The inhibition appears to be due to its ribonucleolytic activity since it (...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: St Clair, D K, Rybak, S M, Riordan, J F, Vallee, B L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299536/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3479795/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.23.8330
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