Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression

Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression analysis of NSCLC cell lines treated with the EGFR TKI, gefitinib, revealed increased levels of FGFR2 and FGFR3 mRNA. Analysis of gefitinib action o...

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Autores principales: Ware, Kathryn E., Marshall, Marianne E., Heasley, Lydia R., Marek, Lindsay, Hinz, Trista K., Hercule, Paula, Helfrich, Barbara A., Doebele, Robert C., Heasley, Lynn E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994708/
https://ncbi.nlm.nih.gov/pubmed/21152424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014117
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