Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression

Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression analysis of NSCLC cell lines treated with the EGFR TKI, gefitinib, revealed increased levels of FGFR2 and FGFR3 mRNA. Analysis of gefitinib action o...

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Detaylı Bibliyografya
Asıl Yazarlar: Ware, Kathryn E., Marshall, Marianne E., Heasley, Lydia R., Marek, Lindsay, Hinz, Trista K., Hercule, Paula, Helfrich, Barbara A., Doebele, Robert C., Heasley, Lynn E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994708/
https://ncbi.nlm.nih.gov/pubmed/21152424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014117
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