Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression

Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression analysis of NSCLC cell lines treated with the EGFR TKI, gefitinib, revealed increased levels of FGFR2 and FGFR3 mRNA. Analysis of gefitinib action o...

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Hlavní autoři: Ware, Kathryn E., Marshall, Marianne E., Heasley, Lydia R., Marek, Lindsay, Hinz, Trista K., Hercule, Paula, Helfrich, Barbara A., Doebele, Robert C., Heasley, Lynn E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994708/
https://ncbi.nlm.nih.gov/pubmed/21152424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014117
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