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The Fibroblast Growth Factor Receptor Signaling Pathway as a Mediator of Intrinsic Resistance to EGFR-specific Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

The EGFR has been targeted through the development of selective tyrosine kinase inhibitors (TKIs) that have proven effective in a subset of non-small cell lung cancer (NSCLC) patients, many bearing gain-of-function EGFR mutations or egfr gene amplification. However, the majority (~80–90%) of NSCLC p...

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Detalhes bibliográficos
Main Authors: Kono, Scott A., Marshall, Marianne E., Ware, Kathryn E., Heasley, Lynn E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763047/
https://ncbi.nlm.nih.gov/pubmed/19501013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drup.2009.05.001
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