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Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding
Transmissible spongiform encephalopathies, or prion diseases, are caused by misfolding and aggregation of the prion protein PrP. These diseases can be hereditary in humans and four of the many disease-associated missense mutants of PrP are in the hydrophobic core: V180I, F198S, V203I and V210I. The...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2994014/ https://ncbi.nlm.nih.gov/pubmed/20932979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.09.060 |
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