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The consequences of pathogenic mutations to the human prion protein
Prion diseases, in which the conformational transition of the native prion protein (PrP) to a misfolded form causes aggregation and subsequent neurodegeneration, have fascinated the scientific community as this transmissible disease appears to be purely protein-based. Disease can arise due to geneti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719504/ https://ncbi.nlm.nih.gov/pubmed/19602567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp039 |
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