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Structural and Dynamic Properties of the Human Prion Protein

Prion diseases involve the conformational conversion of the cellular prion protein (PrP(C)) to its misfolded pathogenic form (PrP(Sc)). To better understand the structural mechanism of this conversion, we performed extensive all-atom, explicit-solvent molecular-dynamics simulations for three structu...

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Bibliografiske detaljer
Main Authors: Chen, Wei, van der Kamp, Marc W., Daggett, Valerie
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026773/
https://ncbi.nlm.nih.gov/pubmed/24606939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.12.053
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