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Structural and Dynamic Properties of the Human Prion Protein
Prion diseases involve the conformational conversion of the cellular prion protein (PrP(C)) to its misfolded pathogenic form (PrP(Sc)). To better understand the structural mechanism of this conversion, we performed extensive all-atom, explicit-solvent molecular-dynamics simulations for three structu...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Biophysical Society
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4026773/ https://ncbi.nlm.nih.gov/pubmed/24606939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.12.053 |
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