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Diverse Effects on the Native β-Sheet of the Human Prion Protein due to Disease-Associated Mutations
Prion diseases are fatal neurodegenerative disorders that involve the conversion of the normal cellular form of the prion protein (PrP(C)) to a misfolded pathogenic form (PrP(Sc)). There are many genetic mutations of PrP associated with human prion diseases. Three of these point mutations are locate...
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| Main Authors: | , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2010
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2976833/ https://ncbi.nlm.nih.gov/pubmed/20949975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101449f |
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