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Conformational diversity in prion protein variants influences intermolecular β-sheet formation

A conformational transition of normal cellular prion protein (PrP(C)) to its pathogenic form (PrP(Sc)) is believed to be a central event in the transmission of the devastating neurological diseases known as spongiform encephalopathies. The common methionine/valine polymorphism at residue 129 in the...

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Detalhes bibliográficos
Main Authors: Lee, Seungjoo, Antony, Lizamma, Hartmann, Rune, Knaus, Karen J, Surewicz, Krystyna, Surewicz, Witold K, Yee, Vivien C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808380/
https://ncbi.nlm.nih.gov/pubmed/19927125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.333
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