Influence of pH on the Human Prion Protein: Insights into the Early Steps of Misfolding

Transmissible spongiform encephalopathies, or prion diseases, are caused by misfolding and aggregation of the prion protein PrP. Conversion from the normal cellular form (PrP(C)) or recombinant PrP (recPrP) to a misfolded form is pH-sensitive, in that misfolding and aggregation occur more readily at...

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Hlavní autoři: van der Kamp, Marc W., Daggett, Valerie
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2010
Témata:
Protein
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042553/
https://ncbi.nlm.nih.gov/pubmed/20923664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.07.063
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