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Influence of pH on the Human Prion Protein: Insights into the Early Steps of Misfolding
Transmissible spongiform encephalopathies, or prion diseases, are caused by misfolding and aggregation of the prion protein PrP. Conversion from the normal cellular form (PrP(C)) or recombinant PrP (recPrP) to a misfolded form is pH-sensitive, in that misfolding and aggregation occur more readily at...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3042553/ https://ncbi.nlm.nih.gov/pubmed/20923664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.07.063 |
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