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Molecular Dynamics Simulations Capture the Misfolding of the Bovine Prion Protein at Acidic pH
Bovine spongiform encephalopathy (BSE), or mad cow disease, is a fatal neurodegenerative disease that is transmissible to humans and that is currently incurable. BSE is caused by the prion protein (PrP), which adopts two conformers; PrP(C) is the native innocuous form, which is α-helix rich; and PrP...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4030982/ https://ncbi.nlm.nih.gov/pubmed/24970211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom4010181 |
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