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Misfolding Pathways of the Prion Protein Probed by Molecular Dynamics Simulations

Although the cellular monomeric form of the benign prion protein is now well characterized, a model for the monomer of the misfolded conformation (PrP(Sc)) remains elusive. PrP(Sc) quickly aggregates into highly insoluble fibrils making experimental structural characterization very difficult. The te...

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Hlavní autoři: Barducci, Alessandro, Chelli, Riccardo, Procacci, Piero, Schettino, Vincenzo
Médium: Artigo
Jazyk:Inglês
Vydáno: Biophysical Society 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305135/
https://ncbi.nlm.nih.gov/pubmed/15556981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.049882
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