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Molecular Dynamics Simulation of Dimeric and Monomeric Forms of Human Prion Protein: Insight into Dynamics and Properties

A central theme in prion protein research is the detection of the process that underlies the conformational transition from the normal cellular prion form (PrP(C)) to its pathogenic isoform (PrP(Sc)). Although the three-dimensional structures of monomeric and dimeric human prion protein (HuPrP) have...

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Autori principali: Sekijima, Masakazu, Motono, Chie, Yamasaki, Satoshi, Kaneko, Kiyotoshi, Akiyama, Yutaka
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303235/
https://ncbi.nlm.nih.gov/pubmed/12885661
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