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Insights into Structure, Stability, and Toxicity of Monomeric and Aggregated Polyglutamine Models from Molecular Dynamics Simulations
Nine genetically inherited neurodegenerative diseases are linked to abnormal expansions of a polyglutamine (polyQ) encoding region. Over the years, several structural models for polyQ regions have been proposed and confuted. The cross-β-spine steric zipper motif, identified recently for the GNNQQNY...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2367175/ https://ncbi.nlm.nih.gov/pubmed/18234827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.118935 |
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