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Insights into Structure, Stability, and Toxicity of Monomeric and Aggregated Polyglutamine Models from Molecular Dynamics Simulations

Nine genetically inherited neurodegenerative diseases are linked to abnormal expansions of a polyglutamine (polyQ) encoding region. Over the years, several structural models for polyQ regions have been proposed and confuted. The cross-β-spine steric zipper motif, identified recently for the GNNQQNY...

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Bibliografske podrobnosti
Main Authors: Esposito, Luciana, Paladino, Antonella, Pedone, Carlo, Vitagliano, Luigi
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367175/
https://ncbi.nlm.nih.gov/pubmed/18234827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.118935
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