Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic and inflammatory contributions of platelet CD40L in atherosclerosis. Although CD40L-deficient (Cd40l(−/−)) platelets exhibited impaired plat...

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Detalhes bibliográficos
Main Authors: Lievens, Dirk, Zernecke, Alma, Seijkens, Tom, Soehnlein, Oliver, Beckers, Linda, Munnix, Imke C. A., Wijnands, Erwin, Goossens, Pieter, van Kruchten, Roger, Thevissen, Larissa, Boon, Louis, Flavell, Richard A., Noelle, Randolph J., Gerdes, Norbert, Biessen, Erik A., Daemen, Mat J. A. P., Heemskerk, Johan W. M., Weber, Christian, Lutgens, Esther
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993630/
https://ncbi.nlm.nih.gov/pubmed/20705757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-261206
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