Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis

AIMS: The importance of transforming growth factor beta (TGFβ) as an immune regulatory cytokine in atherosclerosis has been established. However, the role of TGFβ signalling in dendritic cells (DCs) and in DC-mediated T cell proliferation and differentiation in atherosclerosis is unknown. METHODS AN...

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Hlavní autoři: Lievens, Dirk, Habets, Kim L., Robertson, Anna-Karin, Laouar, Yasmina, Winkels, Holger, Rademakers, Timo, Beckers, Linda, Wijnands, Erwin, Boon, Louis, Mosaheb, Munir, Ait-Oufella, Hafid, Mallat, Ziad, Flavell, Richard A., Rudling, Mats, Binder, Christoph J., Gerdes, Norbert, Biessen, Erik A.L., Weber, Christian, Daemen, Mat J.A.P., Kuiper, Johan, Lutgens, Esther
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Basic Science
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869966/
https://ncbi.nlm.nih.gov/pubmed/22613345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehs106
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