Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis

AIMS: The importance of transforming growth factor beta (TGFβ) as an immune regulatory cytokine in atherosclerosis has been established. However, the role of TGFβ signalling in dendritic cells (DCs) and in DC-mediated T cell proliferation and differentiation in atherosclerosis is unknown. METHODS AN...

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Main Authors: Lievens, Dirk, Habets, Kim L., Robertson, Anna-Karin, Laouar, Yasmina, Winkels, Holger, Rademakers, Timo, Beckers, Linda, Wijnands, Erwin, Boon, Louis, Mosaheb, Munir, Ait-Oufella, Hafid, Mallat, Ziad, Flavell, Richard A., Rudling, Mats, Binder, Christoph J., Gerdes, Norbert, Biessen, Erik A.L., Weber, Christian, Daemen, Mat J.A.P., Kuiper, Johan, Lutgens, Esther
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Basic Science
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869966/
https://ncbi.nlm.nih.gov/pubmed/22613345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehs106
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