Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

The CD40–CD40 ligand (CD40L) signaling axis plays an important role in immunological pathways. Consequently, this dyad is involved in chronic inflammatory diseases, including atherosclerosis. Inhibition of CD40L in apolipoprotein E (Apoe)–deficient (Apoe(−/−)) mice not only reduced atherosclerosis b...

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Main Authors: Lutgens, Esther, Lievens, Dirk, Beckers, Linda, Wijnands, Erwin, Soehnlein, Oliver, Zernecke, Alma, Seijkens, Tom, Engel, David, Cleutjens, Jack, Keller, Anna M., Naik, Shalin H., Boon, Louis, Oufella, Hafid Ait, Mallat, Ziad, Ahonen, Cory L., Noelle, Randolph J., de Winther, Menno P., Daemen, Mat J., Biessen, Erik A., Weber, Christian
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822598/
https://ncbi.nlm.nih.gov/pubmed/20100871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091293
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