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Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain

The activity of phosphodiesterase-5 (PDE5) is specific for cGMP and is regulated by cGMP binding to GAF-A in its regulatory domain. To better understand the regulatory mechanism, x-ray crystallographic and biochemical studies were performed on constructs of human PDE5A1 containing the N-terminal pho...

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Autors principals: Wang, Huanchen, Robinson, Howard, Ke, Hengming
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992248/
https://ncbi.nlm.nih.gov/pubmed/20861010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.141614
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