A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP

Type 1 cGMP-dependent protein kinases (PKGs) play important roles in human cardiovascular physiology, regulating vascular tone and smooth-muscle cell phenotype. A mutation in the human PRKG1 gene encoding cGMP-dependent protein kinase 1 (PKG1) leads to thoracic aortic aneurysms and dissections. The...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Chan, Matthew H., Aminzai, Sahar, Hu, Tingfei, Taran, Amatya, Li, Sheng, Kim, Choel, Pilz, Renate B., Casteel, Darren E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383375/
https://ncbi.nlm.nih.gov/pubmed/32506052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010984
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