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The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43

The type I cGMP-dependent protein kinases (PKGs) are key regulators of smooth muscle tone, cardiac hypertrophy, and other physiological processes. The two isoforms PKGIα and PKGIβ are thought to have unique functions because of their tissue-specific expression, different cGMP affinities, and isoform...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Kalyanaraman, Hema, Zhuang, Shunhui, Pilz, Renate B., Casteel, Darren E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437233/
https://ncbi.nlm.nih.gov/pubmed/28360102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C117.787358
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