Pro-survival Effects of 17β-Estradiol on Osteocytes Are Mediated by Nitric Oxide/cGMP via Differential Actions of cGMP-dependent Protein Kinases I and II

Estrogens promote bone health in part by increasing osteocyte survival, an effect that requires activation of the protein kinases Akt and ERK1/2, but the molecular mechanisms involved are only partly understood. Because estrogens increase nitric oxide (NO) synthesis and NO can have anti-apoptotic ef...

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Bibliographic Details
Main Authors: Marathe, Nisha, Rangaswami, Hema, Zhuang, Shunhui, Boss, Gerry R., Pilz, Renate B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256896/
https://ncbi.nlm.nih.gov/pubmed/22117068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.294959
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