Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-induced Activation

Cyclic GMP-dependent protein kinase (PKG) is a key regulator of smooth muscle and vascular tone and represents an important drug target for treating hypertensive diseases and erectile dysfunction. Despite its importance, its activation mechanism is not fully understood. To understand the activation...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Structure
Main Authors: Kim, Jeong Joo, Lorenz, Robin, Arold, Stefan T., Reger, Albert S., Sankaran, Banumathi, Casteel, Darren E., Herberg, Friedrich W., Kim, Choel
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856591/
https://ncbi.nlm.nih.gov/pubmed/27066748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.03.009
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados