Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-induced Activation

Cyclic GMP-dependent protein kinase (PKG) is a key regulator of smooth muscle and vascular tone and represents an important drug target for treating hypertensive diseases and erectile dysfunction. Despite its importance, its activation mechanism is not fully understood. To understand the activation...

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Veröffentlicht in:Structure
Hauptverfasser: Kim, Jeong Joo, Lorenz, Robin, Arold, Stefan T., Reger, Albert S., Sankaran, Banumathi, Casteel, Darren E., Herberg, Friedrich W., Kim, Choel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856591/
https://ncbi.nlm.nih.gov/pubmed/27066748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.03.009
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