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Crystal structure of cGMP-dependent protein kinase Ib cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation
The R-diastereomer of phosphorothioate analogs of cGMP, Rp-cGMPS, is one of few known inhibitors of cGMP-dependent protein kinase I (PKG I); however, its mechanism of inhibition is currently not fully understood. Here, we determined the crystal structure of the PKG Iβ cyclic nucleotide-binding domai...
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| Publicado no: | FEBS Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5407887/ https://ncbi.nlm.nih.gov/pubmed/27914169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12505 |
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