Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design

[Image: see text] High selectivity of cyclic-nucleotide binding (CNB) domains for cAMP and cGMP are required for segregating signaling pathways; however, the mechanism of selectivity remains unclear. To investigate the mechanism of high selectivity in cGMP-dependent protein kinase (PKG), we determin...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Huang, Gilbert Y., Gerlits, Oksana O., Blakeley, Matthew P., Sankaran, Banumathi, Kovalevsky, Andrey Y., Kim, Choel
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222537/
https://ncbi.nlm.nih.gov/pubmed/25271401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501012v
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