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The amino terminus of cGMP-dependent protein kinase Iβ increases the dynamics of the protein’s cGMP-binding pockets

The type I cGMP-dependent protein kinases play critical roles in regulating vascular tone, platelet activation and synaptic plasticity. PKG I α and PKG Iβ differ in their first ~100 amino acids giving each isoform unique dimerization and autoinhibitory domains with identical cGMP-binding pockets and...

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Bibliografiske detaljer
Main Authors: Lee, Jun H., Li, Sheng, Liu, Tong, Hsu, Simon, Kim, Choel, Woods, Virgil L., Casteel, Darren E.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107041/
https://ncbi.nlm.nih.gov/pubmed/21643460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2010.07.021
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