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The amino terminus of cGMP-dependent protein kinase Iβ increases the dynamics of the protein’s cGMP-binding pockets
The type I cGMP-dependent protein kinases play critical roles in regulating vascular tone, platelet activation and synaptic plasticity. PKG I α and PKG Iβ differ in their first ~100 amino acids giving each isoform unique dimerization and autoinhibitory domains with identical cGMP-binding pockets and...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107041/ https://ncbi.nlm.nih.gov/pubmed/21643460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2010.07.021 |
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