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Crystal Structure of cGMP-dependent Protein Kinase Reveals Novel Site of Interchain Communication
The cGMP-dependent protein kinase (PKG) serves as an integral component of second messenger signaling in a number of biological contexts including cell differentiation, memory and vasodilation. PKG is homodimeric and large conformational changes accompany cGMP binding. However, the structure of PKG...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3168983/ https://ncbi.nlm.nih.gov/pubmed/21893290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.06.012 |
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