Crystal Structure of cGMP-dependent Protein Kinase Reveals Novel Site of Interchain Communication

The cGMP-dependent protein kinase (PKG) serves as an integral component of second messenger signaling in a number of biological contexts including cell differentiation, memory and vasodilation. PKG is homodimeric and large conformational changes accompany cGMP binding. However, the structure of PKG...

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Hauptverfasser: Osborne, Brent W., Wu, Jian, McFarland, Caitlin J., Nickl, Christian K., Sankaran, Banumathi, Casteel, Darren E., Woods, Virgil L., Kornev, Alexandr P., Taylor, Susan S., Dostmann, Wolfgang R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168983/
https://ncbi.nlm.nih.gov/pubmed/21893290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.06.012
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