CD4(+) T-cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the induction and restraint of tumorigenesis, but their role in oncogene inactivation mediated tumor regression is unclear. Here, we show that an intact immune system, specifically CD4(+) T-cells, is require...

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Hlavní autoři: Rakhra, Kavya, Bachireddy, Pavan, Zabuawala, Tahera, Zeiser, Robert, Xu, Liwen, Kopelman, Andrew, Fan, Alice C., Yang, Qiwei, Braunstein, Lior, Crosby, Erika, Ryeom, Sandra, Felsher, Dean W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991103/
https://ncbi.nlm.nih.gov/pubmed/21035406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.10.002
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