Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch

The targeted inactivation of oncogenes offers a rational therapeutic approach for the treatment of cancer. However, the therapeutic inactivation of a single oncogene has been associated with tumor recurrence. Therefore, it is necessary to develop strategies to override mechanisms of tumor escape fro...

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Autori principali: Giuriato, Sylvie, Ryeom, Sandra, Fan, Alice C., Bachireddy, Pavan, Lynch, Ryan C., Rioth, Matthew J., van Riggelen, Jan, Kopelman, Andrew M., Passegué, Emmanuelle, Tang, Flora, Folkman, Judah, Felsher, Dean W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637571/
https://ncbi.nlm.nih.gov/pubmed/17056717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608017103
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