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Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
Oncogene-induced senescence is an important mechanism by which normal cells are restrained from malignant transformation. Here we report that the suppression of the c-Myc (MYC) oncogene induces cellular senescence in diverse tumor types including lymphoma, osteosarcoma, and hepatocellular carcinoma....
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1941831/ https://ncbi.nlm.nih.gov/pubmed/17664422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701953104 |
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