Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

Oncogene-induced senescence is an important mechanism by which normal cells are restrained from malignant transformation. Here we report that the suppression of the c-Myc (MYC) oncogene induces cellular senescence in diverse tumor types including lymphoma, osteosarcoma, and hepatocellular carcinoma....

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Bibliographic Details
Main Authors: Wu, Chi-Hwa, van Riggelen, Jan, Yetil, Alper, Fan, Alice C., Bachireddy, Pavan, Felsher, Dean W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941831/
https://ncbi.nlm.nih.gov/pubmed/17664422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701953104
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