Combined Inactivation of MYC and K-Ras Oncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas

BACKGROUND: Conditional transgenic models have established that tumors require sustained oncogene activation for tumor maintenance, exhibiting the phenomenon known as “oncogene-addiction.” However, most cancers are caused by multiple genetic events making it difficult to determine which oncogenes or...

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Autors principals: Tran, Phuoc T., Fan, Alice C., Bendapudi, Pavan K., Koh, Shan, Komatsubara, Kim, Chen, Joy, Horng, George, Bellovin, David I., Giuriato, Sylvie, Wang, Craig S., Whitsett, Jeffrey A., Felsher, Dean W.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365560/
https://ncbi.nlm.nih.gov/pubmed/18461184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002125
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