MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC

The MYC oncogene is dysregulated in most human cancers and hence is an attractive target for cancer therapy. We and others have shown experimentally in conditional transgenic mouse models that suppression of the MYC oncogene is sufficient to induce rapid and sustained tumor regression, a phenomenon...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Dhanasekaran, Renumathy, Park, Jangho, Yevtodiyenko, Alekesey, Bellovin, David I., Adam, Stacey J., KD, Anand Rajan, Gabay, Meital, Fernando, Hanan, Arzeno, Julia, Arjunan, Vinodhini, Gryanzov, Sergei, Felsher, Dean W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452286/
https://ncbi.nlm.nih.gov/pubmed/32805488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.07.008
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi