MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC

The MYC oncogene is dysregulated in most human cancers and hence is an attractive target for cancer therapy. We and others have shown experimentally in conditional transgenic mouse models that suppression of the MYC oncogene is sufficient to induce rapid and sustained tumor regression, a phenomenon...

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Detaylı Bibliyografya
Yayımlandı:Mol Ther Nucleic Acids
Asıl Yazarlar: Dhanasekaran, Renumathy, Park, Jangho, Yevtodiyenko, Alekesey, Bellovin, David I., Adam, Stacey J., KD, Anand Rajan, Gabay, Meital, Fernando, Hanan, Arzeno, Julia, Arjunan, Vinodhini, Gryanzov, Sergei, Felsher, Dean W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Gene & Cell Therapy 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452286/
https://ncbi.nlm.nih.gov/pubmed/32805488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.07.008
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