MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC

The MYC oncogene is dysregulated in most human cancers and hence is an attractive target for cancer therapy. We and others have shown experimentally in conditional transgenic mouse models that suppression of the MYC oncogene is sufficient to induce rapid and sustained tumor regression, a phenomenon...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Dhanasekaran, Renumathy, Park, Jangho, Yevtodiyenko, Alekesey, Bellovin, David I., Adam, Stacey J., KD, Anand Rajan, Gabay, Meital, Fernando, Hanan, Arzeno, Julia, Arjunan, Vinodhini, Gryanzov, Sergei, Felsher, Dean W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452286/
https://ncbi.nlm.nih.gov/pubmed/32805488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.07.008
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