MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC

The MYC oncogene is dysregulated in most human cancers and hence is an attractive target for cancer therapy. We and others have shown experimentally in conditional transgenic mouse models that suppression of the MYC oncogene is sufficient to induce rapid and sustained tumor regression, a phenomenon...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Mol Ther Nucleic Acids
Autores principales: Dhanasekaran, Renumathy, Park, Jangho, Yevtodiyenko, Alekesey, Bellovin, David I., Adam, Stacey J., KD, Anand Rajan, Gabay, Meital, Fernando, Hanan, Arzeno, Julia, Arjunan, Vinodhini, Gryanzov, Sergei, Felsher, Dean W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452286/
https://ncbi.nlm.nih.gov/pubmed/32805488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.07.008
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares