CD4(+) T-cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the induction and restraint of tumorigenesis, but their role in oncogene inactivation mediated tumor regression is unclear. Here, we show that an intact immune system, specifically CD4(+) T-cells, is require...

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Hauptverfasser: Rakhra, Kavya, Bachireddy, Pavan, Zabuawala, Tahera, Zeiser, Robert, Xu, Liwen, Kopelman, Andrew, Fan, Alice C., Yang, Qiwei, Braunstein, Lior, Crosby, Erika, Ryeom, Sandra, Felsher, Dean W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991103/
https://ncbi.nlm.nih.gov/pubmed/21035406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.10.002
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