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Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90
Activation-induced deaminase (AID) is the mutator enzyme that initiates somatic hypermutation and isotype switching of the antibody genes in B lymphocytes. Undesired byproducts of AID function are oncogenic mutations. AID expression levels seem to correlate with the extent of its physiological and p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2989769/ https://ncbi.nlm.nih.gov/pubmed/21041454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20101321 |
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