Dependence of antibody gene diversification on uracil excision

Activation-induced deaminase (AID) catalyses deamination of deoxycytidine to deoxyuridine within immunoglobulin loci, triggering pathways of antibody diversification that are largely dependent on uracil-DNA glycosylase (uracil-N-glycolase [UNG]). Surprisingly efficient class switch recombination is...

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Bibliographic Details
Main Authors: Di Noia, Javier M., Williams, Gareth T., Chan, Denice T.Y., Buerstedde, Jean-Marie, Baldwin, Geoff S., Neuberger, Michael S.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2007
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150978/
https://ncbi.nlm.nih.gov/pubmed/18070939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071768
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