Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1

The enzyme activation-induced deaminase (AID) deaminates deoxycytidine at the immunoglobulin genes, thereby initiating antibody affinity maturation and isotype class switching during immune responses. In contrast, off-target DNA damage caused by AID is oncogenic. Central to balancing immunity and ca...

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Главные авторы: Orthwein, Alexandre, Zahn, Astrid, Methot, Stephen P, Godin, David, Conticello, Silvestro G, Terada, Kazutoyo, Di Noia, Javier M
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273393/
https://ncbi.nlm.nih.gov/pubmed/22085931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.417
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