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Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1
The enzyme activation-induced deaminase (AID) deaminates deoxycytidine at the immunoglobulin genes, thereby initiating antibody affinity maturation and isotype class switching during immune responses. In contrast, off-target DNA damage caused by AID is oncogenic. Central to balancing immunity and ca...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3273393/ https://ncbi.nlm.nih.gov/pubmed/22085931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.417 |
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